Introduction of a new synthetic route about 1280210-80-1

According to the analysis of related databases, 1280210-80-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1280210-80-1, name is MK-3102 interMediate3, This compound has unique chemical properties. The synthetic route is as follows., name: MK-3102 interMediate3

To a solution of 11 (260 mg, 0.69 mmol) in DMAc (1 mL) was added Ml (288 mg, 0.84 mmol) followed by Ets (0.15 mL, 1.04 mmol) and stirred it for 5 minutes. AcOH (0.10 mL, 1.74 mmol) was added to the reaction mixture and continued the stirring for 30 minutes. NaBH(OAc)3 (0.44 g, 2.09 mmol) was added to the reaction mixture and continued the stirring for 2 days. The reaction mixture was quenched with NH4OH and extracted with EtOAc. Combined organics were concentrated under vacuum. Crude mixture was purified by silica gel chromatography afforded 12. XH NMR (400 MHz, CDC13): delta 7.68 (br. s., 1H), 7.36 – 7.48 (m, 1H), 7.17 – 7.30 (m, 2H), 7.05 (dt, J= 4.40, 8.80 Hz, 1H), 6.91 (d, J= 7.04 Hz, 2H), 6.69 (ddd, J= 3.08, 5.50, 8.73 Hz, 1H), 4.65 (br. s., 1H), 4.55 (br. s., 1H), 4.29 (d, J= 8.22 Hz, 1H), 4.04 (br. s., 2H), 3.59 – 3.82 (m, 2H), 3.30 (s, 3H), 2.47 (br. s., 1H), 1.93 – 2.05 (m, 1H), 1.39 (s, 9H).; Molecular Formula: C27H30F2N4O4S; LCMS purity: 84.2%; Expected: 544.2; Observed: 545.2 (M+l).

According to the analysis of related databases, 1280210-80-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFTU, Tesfaye; WO2014/18350; (2014); A1;,
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