Electric Literature of 563-83-7, These common heterocyclic compound, 563-83-7, name is Isobutyramide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 38 phosphorus pentasulfide (P2S5) (4.58mmol) in ether (8ml) was added 39 isobutylamide 11a (1gm, 11mmol) and the reaction mixture was stirred for 2h at room temperature. The reaction mixture was diluted with brine and extracted with ether. The organic layer was dried over Na2SO4 and evaporated to give crude 40 thioamide. The mixture of crude 40 thioamide and 42 ethyl alpha-bromopyruvate (11.42mmol) in 43 EtOH (10ml) was stirred at reflux temperature for 30min. The solvent was evaporated under vacuum, diluted with EtOAc and washed with 7% aqueous NaHCO3 (3¡Á30mL), the organic layer was dried over Na2SO4 and evaporated to get crude product, which was purified by column chromatography (n-hexane/EtOAc) to afford 44 12a.
Statistics shows that Isobutyramide is playing an increasingly important role. we look forward to future research findings about 563-83-7.
Reference:
Article; Karale, Uttam B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Choudhari, Amit S.; Shukla, Manjulika; Gaikwad, Vikas R.; Mahizhaveni; Chopra, Sidharth; Misra, Sunil; Sarkar, Dhiman; Sriram, Dharmarajan; Dusthackeer, V.N. Azger; Rode, Haridas B.; European Journal of Medicinal Chemistry; vol. 178; (2019); p. 315 – 328;,
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