Some common heterocyclic compound, 108-13-4, name is Malonamide, molecular formula is C3H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 108-13-4
General procedure: An example of the preparation of the amide intermediate was carried out. Blocking the reaction vessel (when the amide intermediate is at a boiling point under normal pressure, etc.At or below the reaction temperature TB below) or to keep the reactor open (when the boiling point of the amide intermediate at normal pressure is higher than the reaction temperature TB described below), stirring is continued (600 r / min), The reaction temperature is changed to TB, and after maintaining the reaction temperature TB for TD hours, the reaction vessel is closed and connected to a vacuum pump, so that the degree of vacuum in the reaction vessel reaches 20-50 mbar (adjusted according to the type of nitrile product) to distill off As a nitrile product. The yield of the nitrile product was calculated and sampled for nuclear magnetic resonance spectroscopy and elemental analysis to characterize the obtained nitrile product. The specific reaction conditions and characterization results are shown in Tables A-6, A-7, A-8, A-9 and A-10 below. These characterization results indicate that the obtained nitrile product has an extremely high purity (99% or more).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108-13-4, its application will become more common.
Reference:
Patent; Sinopec Yangzi Petrochemical Co., Ltd.; Sinopec Corporation; Sun Hailong; Gao Yilong; Wei Yanyu; Chen Xinhua; Miao Jun; Li Na; Kan Lin; Bai Jiye; Chen Shaohui; Yang Aiwu; Xu Yuexing; (32 pag.)CN105016941; (2018); B;,
Amide – Wikipedia,
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