In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H20N2O2
The N- (4- fluoro-2-methoxy-5-nitrophenyl) -4- (1-methyl -1H- indol-3-yl) -5- (trifluoromethyl) pyrimidin – 2-Amine (922mg, 1.0eq), single-Boc protected -N, N’- dimethylethylenediamine (500mg), diisopropylethylamineAmine (2ml), trifluoroethanol were added to a microwave tube 20ml, 100 microwave reaction 2h, the solvent evaporated under reduced pressure,Flash column chromatography to obtain 2 – ((5-methoxy-4- (4- (1-methyl -1H- indol-3-yl) -5- (trifluoromethyl) pyrimidin-2-yl-amineYl) -2-nitrophenyl) (methyl) amino) ethyl (methyl) carbamic acid tert-butyl ester (1.13g, 90percent yield).
The synthetic route of 112257-19-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qilu Pharmaceutical Co., Ltd.; Zhang, Long; Zhao, Shuyong; Chen, Chuanwen; Zhou, Haojie; Yang, Yingying; Chen, Dong; Zheng, Qingmei; Li, Yuhao; Zheng, Shansong; (57 pag.)CN105461695; (2016); A;,
Amide – Wikipedia,
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