Adding a certain compound to certain chemical reactions, such as: 1015-89-0, name is Phenanthridin-6(5H)-one, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1015-89-0, Computed Properties of C13H9NO
Step 1: Synthesis of 2-bromophenanthridone 99.8 g (511 mmol) was added to the phenanthridine dinon 3 ? flask equipped with a plurality of necked stirring arm and is equipped with a condenser. It was added to 1.2 ? of glacial acetic acid and the mixture was stirred at 150 rpm, heated to reflux. A 90 g (562 mmol) Br2 dispersed in 100 acetic acid was added dropwise over 3 hours to a solution being refluxed. After the addition, the mixture was found to be analyzed is about 80% complete. Based on this analysis, it was added dropwise while refluxing the (in the 30 acid) Add 20 g of Br2 in the mixture. After the addition, the analysis is> 90% completed. It was added dropwise to 20 g Br2 end (30 of the acid) and the mixture was stirred for 1 hour after addition. Final analysis> was 97%. The mixture was cooled, water was added in 1 ?, and the mixture was filtered. By stirring in a wet solids aqueous solution of sodium thiosulfate was decomposed the residual bromine, and filtered again. thisRinse the solid with H2O, and allowed to dry under vacuum to remove residual water. Thereafter, the solid was recrystallized from nitrobenzene (> ? 2), and collected on a funnel to give 128 g of 2-bromo-phenanthridine dinon (90.8% yield).
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Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; NOLIS, DAVID B; LIN, CHOOK; MCKINSEY, PETER BODON; CHAI, CHUI LEE; WALTERS, ROBERT W; PIERS, SCOTT A; BROWN, CORY S; IGOR, WALTER H; (101 pag.)KR2016/30582; (2016); A;,
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