Adding a certain compound to certain chemical reactions, such as: 104863-65-2, name is N-Methoxy-N-methylpropionamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 104863-65-2, name: N-Methoxy-N-methylpropionamide
The reaction formula of this embodiment is as follows:In a 25 ml reaction flask, add compound 1a (0.3 mmol, 0.1561 g), compound 2i (15 mmol, 1.7573 g), water (30 muL), DCM (5 mL) to dissolve the above materials, and stir the reaction at 60 C. The reaction time is 3 h. After the reaction was completed, the solvent was removed by spin-drying, and the residue was subjected to flash column chromatography (PE: EA = 20: 1) to obtain pure product 3ai (0.0534 g) with a yield of 76%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Methoxy-N-methylpropionamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Xuzhou Medical University; Wu Nan; Xu Zhou; Mi Jiajia; Li Chuang; Yuan Changyong; Zheng Yan; (15 pag.)CN110668937; (2020); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics