Related Products of 885-70-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 885-70-1, name is 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 20 L-5,11-Dihydro-11-[[6-methyl-2,6-diazabicyclo[3.3.0]oct-2-yl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 2.6 g (0.021 mole) of L-2-methyl-2,6-diazabicyclo [3.3.0]octane were added dropwise to a mixture consisting of 11.2 ml of a 20% strength solution of phosgene in toluene, 50 ml of acetonitrile and 2.4 g (0.023 mole) of anhydrous sodium carbonate while externally cooling with ice. After 60 minutes, 4.5 g (0.021 mole) of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one were added and the mixture was heated under reflux for 4 hours. The hot mixture was filtered, the precipitate was washed three times using 10 ml of hot acetonitrile each time and the combined filtrates were concentrated in vacuo to a total volume of 15 ml. The solution was cooled in an ice bath and the resulting crystal paste was filtered under suction. Recrystallisation from acetonitrile produced 2.1 g (27% of theory) of colourless crystals of m.p. 220-222 C., identical to the preparation made as in Example 6c according to mixed melting point and spectroscopic data. 5,11-Dihydro-11-[[7-methyl-3,7-diazabicyclo[3.3.0]oct-3-yl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one of m.p. 157-159 C. (acetonitrile) 5,11-dihydro-11-[[10-methyl-4,10-diazatricyclo[5.2.1.02,6 ]dec-4- yl]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one of m.p. 218-220 C. (ethyl acetate) were obtained in corresponding manner.
The chemical industry reduces the impact on the environment during synthesis 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Rudolf; Klaus; Engel; Wolfhard; Eberlein; Wolfgang; Trummlitz; Gunter; Mihm; Gerhard; Doods; Henri; Mayer; Norbert; US5179090; (1993); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics