Electric Literature of 112257-19-9,Some common heterocyclic compound, 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate, molecular formula is C9H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Compound 79-4a (510 mg, 1.57 mmol) in DCE (5 mL) at 25¡ã C. was added tert-butyl N-methyl-N-[2-(methylamino)ethyl]carbamate (300 mg, 1.59 mmol, 1.01 eq). The mixture was stirred for 1 h, AcOH (52.50 mg, 0.874 mmol, 0.0556 eq) and NaBH(OAc)3 (666.47 mg, 3.14 mmol, 2 eq) were added and the mixture was stirred at RT for 3 hr, then partitioned between saturated aq. NaHCO3 (50 mL) and EtOAc (100 mL). The organic layer was washed with brine (50 mL), dried (Na2SO4), filtered and concentrated under reduced pressure to give the title compound (0.77 g, 1.38 mmol, 88percent yield) as yellow oil. MS (ES+) C26H42F2N4O3, requires: 496, found: 497 [M+H]+.
The synthetic route of 112257-19-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Board of Regents, The University of Texas System; DI FRANCESCO, Maria Emilia; JONES, Philip; MCAFOOS, Timothy Joseph; (166 pag.)US2019/270739; (2019); A1;,
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