Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121496-39-7, name is tert-Butyl benzyl(2-hydroxyethyl)carbamate, A new synthetic method of this compound is introduced below., SDS of cas: 121496-39-7
Under nitrogen atmosphere, to an ice-cooled solution of 4-iodophenol (15.40 g), triphenylphosphine (22.03 g), and tert-butyl benzyl (2-hydroxyethyl) carbamate (21.05 g) in tetrahydrofuran (123 ml) was added diethyl azodicarboxylate (14.58 g) in tetrahydrofuran (31 ml) for 25 minutes, and the mixture was stirred at room temperature for 2 hours. After being concentrated, the mixture was treated with HEXANE/ETHYL acetate (5/1, 180 ml). The precipitate formed was filtered off, the filtrate was concentrated, and the residue was purified by column chromatography (silica gel, hexane/ethyl acetate) to give tert-butyl benzyl [2- (4- iodophenoxy) ethyl] carbamate (7.17 G) as a colorless oil. NMR (CDC13, B) : 1.45 (9H, s), 3.58 (2H, br s), 4.07 (2H, br s), 4.55 (2H, s), 6.62 (2H, d, J=8Hz), 7.10- 7.40 (5H, m), 7.53 (2H, d, J=8HZ) (+) ESI-MS (m/z): 476 (M+Na) +
The synthetic route of 121496-39-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD; WO2004/45610; (2004); A1;,
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