Synthetic Route of 96-30-0,Some common heterocyclic compound, 96-30-0, name is 2-Chloro-N-methylacetamide, molecular formula is C3H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The preparation mother liquid (129 mL) of O,O-dimethyl-S-(N-methylcarbamoylmethyl)phosphorothioate in Example 1 which had been reused 6 times was added with methanol to 130 ml. Add 32.82 g (0.2 mol) of the sodium O,O-dimethylthiophosphate prepared in the step (2), 21.5 g (0.2 mol) of 2-chloro-N-methylacetamide prepared in the step (1) and 1.66 g (0.01 mol) of potassium iodide were reacted at 65 C for 10 hours, and then the heating was stopped. After naturally dropping to room temperature, the salt formed by the reaction is filtered off, Rotating to remove the solvent, That is, 40.98 g of light yellow O,O-dimethyl-S-(N-methylcarbamoylmethyl)phosphorothioate was obtained, the yield was 96.1%; The purity by GC was 95.22%; the water content of the product was 0.044%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N-methylacetamide, its application will become more common.
Reference:
Patent; Henan Chemical Institute Co., Ltd.; Huo Erfu; Cheng Weiqin; Feng Ming; Wang Bonan; Wang Yanhua; Chang Shuhao; Dong Guangxia; Yang Shuai; Wang Yinan; (16 pag.)CN109651432; (2019); A;,
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