Reference of 122334-37-6, These common heterocyclic compound, 122334-37-6, name is 4-Chloro-N-methoxy-N-methylbenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1; 3-(4-chloro-phenyl)-2-(2>4-dichloro-phenyl)-4,5,6,7-tetraliydro-2H- indazole-7-carboxylic acidpiperidin-1-ylamide (Cpd 33); To a solution of LHMDS (21 mL, 2.1 mmol) in 50 mL of anhydrous THF under a nitrogen atmosphere at -78 0C was added 2-oxo-cyclohexanecarboxylic acid ethyl ester Compound Ia (1.80 g, 10.0 mmol) in 10 mL of anhydrous THF. The resultant homogeneous mixture was left to stir at -78 0C for 40 min followed by the drop wise addition of 4-chloro-N-methoxy-N-methyl-benzamide Compound Ib (2.0 g, 10 mmol) in 10 mL of anhydrous THF. The reaction mixture was allowed to stir for 18 hours and allowed to warm to ambient temperature. The reaction mixture was quenched with water (50 mL) and the organic layer was extracted with EtOAc (200 mL) and washed with brine, separated and dried with anhydrous Na2SO4, then filtered and concentrated in vacuo to yield 3-(4-chloro-benzoyl)-2-oxo-cyclohexanecarboxylic acid ethyl ester Compound Ic (1.7 g) as an oil, which was used in the next step without further purification.
Statistics shows that 4-Chloro-N-methoxy-N-methylbenzamide is playing an increasingly important role. we look forward to future research findings about 122334-37-6.
Reference:
Patent; JANSSEN PHARMACEUTICA, NV; WO2007/95513; (2007); A1;,
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