Adding a certain compound to certain chemical reactions, such as: 956434-30-3, name is tert-Butyl 8-chloro-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 956434-30-3, Safety of tert-Butyl 8-chloro-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate
(Step 1) A solution of the compound (0.300 g) obtained in Example 29, step 1, 2-methylpiperidine (185.7 muL), XPhos (0.030 g) and tBuONa (0.152 g) in toluene (10 mL) was degassed with argon gas, Pd2(dba)3 (0.019 g) was added, and the mixture was stirred at 100C for 1.5 hr under an argon atmosphere. The reaction mixture was poured into water, and the resultant product was extracted with ethyl acetate. The organic layer was washed with water and brine and dried, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 20?40% ethyl acetate/hexane) and recrystallized from pentane to give tert-butyl 8-(2-methylpiperidin-1-yl)-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate (0.106 g, 29%) as a white powder. 1H-NMR(CDCl3): delta 1.12(3H,d,J=6.8Hz), 1.42(9H,s), 1.40-1.80(6H,m), 2.88(1H,dt,J=2.7,12.9Hz), 3.75-3.85(2H,m), 4.05-4.38(5H,m), 4.58(1H,brs like), 6.26(1H,d,J=8.3Hz), 7.60(1H,d like)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 8-chloro-2,3-dihydropyrido[3,2-f][1,4]oxazepine-4(5H)-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2018863; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics