Electric Literature of 17641-08-6,Some common heterocyclic compound, 17641-08-6, name is 2-Chloro-N-(3-methoxyphenyl)acetamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of 4-(5-mercapto-1,3,4-oxadiazol-2-yl)benzenesulfonamide (9) (1mmol), various substituted 2-chloro-N-phenylacetamide 11a-j (1mmol) and K2CO3 (1.5mmol) was refluxed in acetone (15ml) for 3-4h. The reaction was monitored with TLC and after completion of the reaction, excess of solvent was evaporated and diluted with water (about 100ml). The precipitated was separated out, filtered washed with water and recrystallized with an appropriate solvent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-N-(3-methoxyphenyl)acetamide, its application will become more common.
Reference:
Article; Angeli, Andrea; Kumar, Rajiv; Sharma, Pawan K.; Sharma, Vikas; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 193; (2020);,
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