Some common heterocyclic compound, 22117-85-7, name is 2-Methoxy-5-sulfamoylbenzoic acid, molecular formula is C8H9NO5S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Methoxy-5-sulfamoylbenzoic acid
(2) N-(3,5-Bis(trifluoromethyl)phenyl]-2-methoxy-5-sufamoylbenzamide. Using 2-methoxy-5-sulfamoylbenzoic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 24 gave the title compound. Yield: 24.2%. 1H-NMR(DMSO-d6): delta 3.97(3H, s), 7.38(2H, s), 7.39(1H, d, J=8.7Hz), 7.85(1H, s), 7.96(1H, dd, J=8.7, 2.4Hz), 8.06(1H, d, J=2.4Hz), 8.43(2H, s), 10.87(1H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 22117-85-7, its application will become more common.
Reference:
Patent; Institute of Medicinal Molecular Design, Inc.; EP1352650; (2003); A1;,
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