Adding a certain compound to certain chemical reactions, such as: 4793-24-2, name is 2-Chloro-4-fluoro-5-sulfamoylbenzoic acid, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4793-24-2, COA of Formula: C7H5ClFNO4S
THF (3 ml_), 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide (70 mg, 0.198 mmol), 5-(aminosulfonyl)-2-chloro-4-fluorobenzoic acid (50.1 mg, 0.198 mmol), HATU (75.2 mg, 0.198 mmol) and DIPEA (0.069 ml_, 0.395 mmol) were combined and the reaction mixture was stirred at rt for 45 min. Burgess Reagent (236 mg, 0.990 mmol) was added and the reaction was stirred overnight. The reaction mixture was diluted with ethyl acetate and washed with water. The solvent was removed and the crude material was purified via silica gel chromatography to give 67 mg of the title compound. 1H NMR (CDCI3) delta 8.46 (d, 1 H), 7.47 (d, 1 H), 7.31-7.36 (m, 2 H), 7.23 (m, 1 H), 7.00-7.05 (m, 1 H), 6.94 (m, 1 H), 5.37 (s, 2 H), 4.39 (s, 2 H).
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Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/157330; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics