Electric Literature of 19047-31-5,Some common heterocyclic compound, 19047-31-5, name is 2-Chloro-N-cyclopropylacetamide, molecular formula is C5H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2-chloro-N-cyclopropylacetamide (1.33 g, 10 mmol), 3- bromobenzenethiol (1.6 g, 8.5 mmol) and K2CO3 (4.8 g, 35 mmol) in 30 mL of acetone was heated at 70 C overnight. The mixture was filtered and concentrated to give a residue, which was purified by column chromatography (PE/EA, 1/1) to give the title compound (2.4 g, 96%) as a white solid. 1H NMR delta (300 MHz, CDC13) 7.39 (1H, m), 7.31 (1H, m), 7.14 (2H, m), 6.71 (1H, s), 3.58 (2H, s), 2.64-2.77 (1H, m), 0.73-0.84 (2H, m), 0.41 (2H, m); m/e 286 (M+H)+.
The synthetic route of 19047-31-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KADMON CORPORATION, LLC; BOXER, Michael; RYAN, John; TONRA, James; WO2014/55999; (2014); A2;,
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