Reference of 782-45-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 782-45-6 name is 4-Amino-N-phenylbenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A solution of triphosgene (1 eq) in 5 mL dry THF was cooled to -78C. A solution of 4-(4-morpholin-4-yl-pyrido[2,3-d]pyrimidin-2-yl)-phenylamine HCl salt (3 eq) and N,N-diisopropylethylamine (4.8 eq) in dry THF (5 mL) was added dropwis to the triphosgene solution. The mixture was warmed to room temperature and stirred for 50 min. A solution of the second amine (3 eq.) and N,N-diisopropylethylamine (2.5 eq) in dry THF (5 mL) was added dropwise. The reaction mixture was stirred for 48-72 h. The solvent was removed under reduced pressure then saturated aqueous sodium bicarbonate solution (5 mL) was added to the residue to neutralize any acid. Then the solvent was removed under reduced pressure. The crude product was dissolved in 3 mLof DMSO, filtered and purified reversed phase HPLC (15 min gradient acetonitrile in water, 0.1% trifluoroacetic acid or formic acid as a m odifier).The pure product was obtained as trifluoroacetate or formate salt.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-N-phenylbenzamide, and friends who are interested can also refer to it.
Reference:
Article; Al-Ashmawy, Aisha A.K.; Ragab, Fatma A.; Elokely, Khaled M.; Anwar, Manal M.; Perez-Leal, Oscar; Rico, Mario C.; Gordon, John; Bichenkov, Eugeney; Mateo, George; Kassem, Emad M.M.; Hegazy, Gehan H.; Abou-Gharbia, Magid; Childers, Wayne; Bioorganic and Medicinal Chemistry Letters; vol. 27; 14; (2017); p. 3117 – 3122;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics