Reference of 758-96-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 758-96-3 name is N,N-Dimethylpropionamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Weigh 4-methylbenzothiazole (0.5mmol, 75mg), K2S2O8 (2mmol, 0.54g) and Eosin Y (0.01mmol, 6.5mg) in a 25mL Schlenk reaction tube,Then add N, N-dimethylpropionamide (38mmol, 3.8g), put it under the LED white light of 20W power to react, stir the reaction at room temperature, monitor the progress of the reaction with TLC, the reaction ends after 24h, and the reaction solution is concentrated The solvent was removed, and the concentrated solution was separated by column chromatography (eluent: petroleum ether / ethyl acetate with a volume ratio of 5: 1) to obtain a yellow oil, that is, the derivative Im. The yield was 72%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N,N-Dimethylpropionamide, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University of Technology; Weng Jianquan; Xu Wenxiu; Dai Xiaoqiang; Liu Xinghai; (11 pag.)CN110432282; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics