Reference of 5900-59-4,Some common heterocyclic compound, 5900-59-4, name is 2-Amino-4-chlorobenzamide, molecular formula is C7H7ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE A To a mixture of 0.34 g of 2-amino-4-chlorobenzamide, 0.57 g of monochloroacetic acid, 0.90 g of sodium iodide and 0.24 g of magnesium oxide was added 2 ml of dimethylformamide and the mixture was stirred at a temperature between 90¡ã and 100¡ã C. for 2.5 hours. After cooling, the reaction mixture was poured into 50 ml of a 2.6percent aqueous sodium carbonate solution. The resulting precipitates were filtered off and the filtrate was extracted with 50 ml of chloroform. The aqueous layer was acidified with concentrated hydrochloric acid to precipitate crystals. The crystals were collected by filtration and recrystallized from aqueous methanol to obtain 0.20 g of N-(2-carbamoyl-5-chlorophenyl)glycine as needles having a melting point of 217¡ã-222¡ã C. (decomposition). Elemental Analysis for C9 H9 O3 N2 Cl: Calcd.(percent): C, 47.28; H, 3.97; N, 12.25. Found (percent): C, 47.11; H, 3.74; N, 12.32.
The synthetic route of 5900-59-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daiichi Seiyaku Co., Ltd.; US4297357; (1981); A;,
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