Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16313-66-9, name is 2-Amino-5-bromobenzamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H7BrN2O
General procedure: 3.3.1 6-Bromo-8-iodo-2-phenylquinazolin-4(3H)-one (4a) A stirred mixture of 2 (1.00 g, 2.94 mmol), benzaldehyde (0.37 g, 3.52 mmol) and iodine (1.49 g, 5.88 mmol) in ethanol (100 mL) was refluxed for 7 h and then allowed to cool to room temperature. The mixture was quenched with an ice-cold aqueous sodium thiosulfate solution and the precipitate was filtered and recrystallized to afford 4a as a white solid (1.10 g, 87%), mp>345 C; numax (ATR) 527, 552, 636, 688, 698, 848, 946, 1129, 1291, 1384, 1446, 1470, 1563, 1598, 1658, 3073, 3164 cm-1; deltaH (500 MHz, DMSO-d6) 7.56-7.62 (m, 3H), 8.20 (d, J=2.0 Hz, 1H), 8.25-8.29 (m, 2H), 8.49 (d, J=2.0 Hz, 1H), 12.86 (s, 1H); deltaC (125 MHz, DMSO-d6) 103.5, 119.7, 122.9, 128.5, 128.9, 129.2, 132.4, 132.7, 145.9, 148.1, 153.7, 161.7; m/z 427 (100, MH+); HRMS (ES): MH+, found 426.8937. C14H979BrIN2O+ requires 426.8943.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Paumo, Hugues K.; Mphahlele, Malose J.; Rhyman, Lydia; Ramasami, Ponnadurai; Tetrahedron; vol. 72; 1; (2016); p. 123 – 133;,
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