In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 864448-41-9 as follows. Formula: C11H20N2O3
To a mixture of 3-oxa-7,9-diaza-bicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester (171 mg, 0.75mmol) and DIPEA(0.45 mL, 2.5 mmol) in CH2C12 (10 mL) was added (R)-6- bromomethyl-4-(2-chloro-4-fluoro-phenyl)-2-thiazol-2-yl-l,4-dihydro-pyrimidine-5-carboxylic acid methyl ester(222 mg, 0.5 mmol). The mixture was stirred at room temperature for 16 hours The mixture was concentrated in vacuo. The residue was purified by flash column chromatography to afford 9-[(R)-6-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2- yl-3,6-dihydro-pyrimidin-4-ylmethyl]-3-oxa-7,9-diaza-bicyclo[3.3.1]nonane-7-carboxylic acid tert-butyl ester as yellow oil (0.28 g, 94%). MS: calc’d (MH+) 592, measured (MH+) 592.
According to the analysis of related databases, 864448-41-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; KOU, Buyu; LI, Gangqin; LIN, Xianfeng; LIU, Haixia; SHEN, Hong; SHI, Houguang; WU, Guolong; ZHANG, Zhisen; ZHOU, Mingwei; ZHU, Wei; WO2014/184328; (2014); A1;,
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