Electric Literature of 758-96-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 758-96-3 as follows.
General procedure: To a solution of 5-chloro-N-cyanothiophene-2-carboximidamide in CH3CN was added N,N-dimethylacetamide and POCl3. The mixture was stirred at 70 C overnight under N2. TLC showed starting material was consumed. The mixture was then poured into NaHCO3 (aq) carefully and the precipitate collected. The dried compound was taken to the next step without further purification.
According to the analysis of related databases, 758-96-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Hagen, Timothy J.; Mo, Xuesheng; Burgin, Alex B.; Fox III, David; Zhang, Zheng; Gurney, Mark E.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 4031 – 4034;,
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