Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50667-69-1, name is 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows., name: 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide
Intermediate 1 Preparation of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid To a solution of 2-chlorobenzoic acid (930.0 gm,5.96 mol) in cone, sulphuric acid (5580 ml), 2,2,2-trifluoro-N-(hydroxymethyl)acetamide (930.0 gm ,6.0 mol) was added at 20 C and the reaction mixture was stirred for 15.0 h at 25-30 C. After the completion of the reaction, the reaction was slowly quenched with cold water (37.0 lit) at 10-15 C. The precipitated product was filtered and dried. The obtained product was purified using mixture of toluene and methylethylketone (7:1 x 4 times) to obtain 580.0 gm of the tittle compound having chemical purity of 98.0%, determined by HPLC.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50667-69-1.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; MUTHUKAMAN, Nagarajan; GHARAT, Laxmikant Atmaram; KADAM, Suresh Mahadev; GAVHANE, Sachin; KHANDAGALE, Sandeep Bandu; NIRGUDE, Sunil Pandurang; (59 pag.)WO2016/199104; (2016); A1;,
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