Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53250-82-1, name is 4-(Methylsulfonamido)aniline, A new synthetic method of this compound is introduced below., SDS of cas: 53250-82-1
Example 46 (2464) N-(4-((7-Chloro-5-hydroxy-1 ,1 -dioxido-2H-benzore1H ,2,41thiadiazin-3- yl)amino)phenyl)methanesulfonamide (2465) (2466) To a stirred solution of N-(4-aminophenyl)methanesulfonamide (143 mg), KH2P04 (105 mg) in t-BuOH (10 mL) at 0 C was added 3-bromo-7-chloro-5-hydroxy-4H- benzo[e][1 ,2,4]thiadiazine 1 ,1 -dioxide (lnt-3, 200 mg) in portions. The reaction mixture was then stirred at 80 C for 16 hr, cooled to RT, and diluted with cold water. The resulting solid was collected by filtration, washed with diethyl ether and dried under vacuum to afford the titled compound (177.7 mg). LCMS m/z 416.92 (M+H). NMR after D20 exchange (400 MHz, DMSO-c/e) delta ppm 2.97 (s, 3 H) 7.09 (d, J=1 .97 Hz, 1 H) 7.18 (d, J=2.19 Hz, 1 H) 7.25 (d, J=8.77 Hz, 2 H) 7.48 (d, J=8.77 Hz, 2 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ADAMS, Jerry Leroy; ATOR, Laura E.; DUFFY, Kevin J.; GRAYBILL, Todd L.; KIESOW, Terence John; LIAN, Yiqian; MOORE, Michael Lee; RALPH, Jeffrey M.; RIDGERS, Lance Howard; (370 pag.)WO2017/98421; (2017); A1;,
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