Application of 459817-82-4, The chemical industry reduces the impact on the environment during synthesis 459817-82-4, name is tert-Butyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide, I believe this compound will play a more active role in future production and life.
General procedure: To a 2M solution of isopropylmagnesium chloride (20 ml 0.040 mol) in diethyl ether was added 3-iodo benzotrifluoride (11.05 g 5.85 ml 0.040 mol) at -12C and the mixture was kept in the freezer (-20C) for 18h. To the resulting clear solution was added 0.100 g cuprous (I) iodide (0.00032 mol) and the mixture was stirred at room temperature for 2h. A clear slighthly yellow solution was obtained.To a suspension of the corresponding sulfamidate (2a-e) (0.0050 mol) in 5 ml diethyl ether was added drop wise 5.0 ml of the stock solution of m-(trifluoromethyl)phenylmagnesium chloride (ca 0.001 mol) as prepared above at -12C and the mixture was stirred at -12C for 2h. To the resulting suspension was added 10 ml of a 10% aqueous citric acid solution and the mixture was stirred at room temperature for 0.5h. The phases were separated and the organic phase was dried over magnesium sulfate and evaporated to dryness. The resulting residue was purified by kugelrohr distillation (0.4 mBar; 95C) or by recrystallisation from heptane as indicated in the table.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Hebeisen, Paul; Weiss, Urs; Alker, Andre; Staempfli, Andreas; Tetrahedron Letters; vol. 52; 41; (2011); p. 5229 – 5233;,
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