Application of 35303-76-5, These common heterocyclic compound, 35303-76-5, name is 4-(2-Aminoethyl)benzenesulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
During DMF (5mL) (S) -4- (3 – ((S) -6- (bis ((1- (2-tert-butoxy-2-oxoethyl)-lH-imidazol-2-yl) methyl) amino)-1-tert-butoxy-1-oxo-hexane-2-yl) ureido) -5-tert-butoxy-5-oxo-pentanoic acid(80mg, 0.098mmol), 4- (2- aminoethyl) benzenesulfonamide amide (30mg,0.15mmol), 2- (1-H-7- aza-benzotriazol-1-yl) -1,1,3,3-hexafluorophosphatetetramethyluronium methane aminium (HATU, 50mg , 0.17 mmol), and was DIPEAsolution containing a (0.50 mL) was stirred overnight at 40 ¡ã C. The solventwas evaporated under reduced pressure, and to produce a residue which was usinga gradient containing 0-20percent MeOH in DCM and purified by Biotage SP4, (S) -tert-butyl 6- (bis ( (1- (2-tert- butoxy-2-oxoethyl)-lH-imidazol-2-yl) methyl)amino) -2- (3 – ((S) -1-tert- butoxy-1,5-dioxo – 5-(4-sulfamoyl-phenethyl-amino) pentan-2-yl) ureido) hexane acid (100mg,Resultedin 100percent).
Statistics shows that 4-(2-Aminoethyl)benzenesulfonamide is playing an increasingly important role. we look forward to future research findings about 35303-76-5.
Reference:
Patent; MOLECULAR INSIGHT PHARMACEUTICALS INCORPORATED; BABICH, JOHN W; (133 pag.)JP5856247; (2016); B2;,
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