The chemical industry reduces the impact on the environment during synthesis tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate. I believe this compound will play a more active role in future production and life.
Synthetic Route of 185693-02-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 185693-02-1, name is tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Example 13: Synthesis of 7-(furan-3-ylcarbonyl)-2,7-diazabicyclo[3.3.0]octane; The following procedures are exemplary of those used to produce various 7- (heteroarylcarbonyl)-2,7-diazabicyclo[3.3.0]octanes. To a solution of furan-3-carboxylic acid (0.084 g, 0.75 mmol) in anhydrous THF (5 ml.) was added HBTU (0.28 g, 0.75 mmol), followed by triethylamine (0.2 g, 2 mmol). After stirring at ambient temperature for 10 min, the mixture was treated with a solution of tert- butyl 2,7-diazabicyclo[3.3.0]octane-2-carboxylate (commercially available) (0.106 g, 0.500 mmol) in THF (2 ml_). The reaction mixture was stirred for 16 h at ambient temperature. The solvent was removed by rotary evaporation, and the residue was partitioned between ethyl acetate (5 ml.) and saturated sodium bicarbonate (2 ml_). The organic layer was concentrated, and the residue was purified by reverse phase HPLC to give tert-butyl 7- (furan-3-ylcarbonyl)-2,7-diazabicyclo[3.3.0]octane-2-carboxylate. This was dissolved in 1 :1 mixture of trifluoroacetic acid and dichloromethane (1 mL) and the mixture was shaken at ambient temperature for 1 h. The volatiles were removed under reduced pressure, and the residue was dried overnight at high vacuum, to give 0.050 g of 7-(furan-3-ylcarbonyl)-2,7- diazabicyclo[3.3.0]octane as a syrup (0.050 g, 32% yield).
The chemical industry reduces the impact on the environment during synthesis tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; TARGACEPT, INC.; WO2008/112734; (2008); A1;,
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