Application of 121492-06-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a cooled (0 C) solution of NMethylNbocethylendiamine (05 mL, 279 mmol) and NaCNBH3 (140 mg, 223 mmol) in MeOH (10 mL) and acetic acid (05 mL) was added a solution of 2,4,6trimethoxyhenzaldehyde (0 547 mg 279 mmol) in EtOH (10 mL). The mixture was stirrcd at RI for 2 h, acidificd with 2 M HCI (1 mL) and neutralized withsaturated aqueous Na2CO3 (50 mL). Evaporation of all volatiles, DCM extraction of the resulting aqueous slurry and concentration of the organic fractions yielded N MethylNbocN? tmobethy1endiamine (5a) as a crude oil which was purified by RPHPLC.Yield 593 ing (L52 mmol)MS. rn z 377 35 [M+Na], (calculated = 377 14).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-(2-Aminoethyl)-N-methylamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASCENDIS PHARMA RELAXIN DIVISION A/S; SPROG?E, Kennett; CLEEMANN, Felix; RAU, Harald; HASSEPASS, Nicole; WEGGE, Thomas; ZETTLER, Joachim; BERNHARD, Ana; WO2015/67791; (2015); A1;,
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