Reference of 108468-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A. {(S)-l-[4-(tert-Butoxycarbonylamino-methyl)-benzylcarbamoyl]-2-phenyl-ethyl}- carbamic acid benzyl ester (S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid 2,5-dioxo-pyrrolidin-l-yl ester (4.25g, 10.72mmol) was dissolved in CH2CI2 (100 mL). This solution was cooled to 0C. l-(N-Boc- Aminomethyl)-4-(aminomethyl)benzene (2.79g, 11.79mmol) was added followed by triethylamine (3.25g, 32.16mmol). After 18 hrs at 0C to room temperature reaction mixture was diluted with chloroform (100 mL) and washed with NaHC03 (1×30 mL), water (1×30 mL), brine (1×30 mL), dried (Na2S04) evaporated in vacuo giving a yellow oil. The residue was triturated with Pet. Ether (60-80C) and EtOAc to give a white solid identified as {(S)-l-[4-(tert- butoxycarbonylamino-methyl)-benzylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (3.88g, 7.49mmol, 70%). [M+H]+ = 518.28, 540.32 (M+Na).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; KALVISTA PHARMACEUTICALS LIMITED; EVANS, David Michael; DAVIE, Rebecca Louise; EDWARDS, Hannah Joy; ROOKER, David Philip; WO2013/5045; (2013); A1;,
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