Adding a certain compound to certain chemical reactions, such as: 37073-15-7, name is 1-(Methylsulfonyl)-1H-benzo[d][1,2,3]triazole, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37073-15-7, category: amides-buliding-blocks
To a solution of 2-(4-fluorophenyl)acetonitrile (2 g, 15 mmol) in DMSO (15 mL) at 8 C was added t-BuOK (2.84 g, 29 mmol). The mixture was stirred for 10 min and a solution of compound 6-1 (2.92 g, 15 mmol) in DMSO (40 mL) was then added slowly via an addition funnel. The reaction mixture was warmed to RT and stirred overnight, quenched with water, and neutralized with saturated aq. NH4C1. The mixture was extracted with EtOAc (3×100 mL). The combined organic layers were washed with water, brine, dried over MgS04, and filtered. The filtrate was concentrated and purified by silica gel column chromatography (PE/EtOAc = 5: 1) to give 6-2.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CUMMING, Jared, N.; KAELIN, David Earl, Jr.; SCOTT, Jack, D.; WU, Wen-Lian; BURNETT, Duane, A.; WO2014/99794; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics