Adding a certain compound to certain chemical reactions, such as: 67341-01-9, name is tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67341-01-9, Recommanded Product: 67341-01-9
Synthesis of S3, a compound of formula I: Weigh 1.0 g, 1.0 equiv. of the compound of formula X in the reactor, based on the compound of formula X,1.2equiv. of the compound of formula IV is added to the reactor, 1.5 equiv. of triphenylphosphine, at room temperature, and the DIAD of 2.5equiv. is added to the reactor. After stirring the reaction for 5.0 h at room temperature, the reaction solution was concentrated to dryness. Concentrated residue in ethyl acetate and distribute in 1.0N aqueous hydrochloric acid, separate the organic phase, after washing the organic phase with a saturated aqueous solution of sodium hydrogencarbonate and brine, the organic phase was dried over sodium sulfate and concentrated. The concentrate is separated by column chromatography to give a compound of formula I in a yield of 80%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-hydroxy-1-phenylethyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Anhui Huasheng Pharmaceutical Technology Co., Ltd.; Hu Zhigang; Xu Liangzhi; He Darong; Du Xiaopeng; Qian Zhujin; He Yong; Chen Yuelei; (14 pag.)CN109761913; (2019); A;,
Amide – Wikipedia,
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