Application of 1314538-55-0,Some common heterocyclic compound, 1314538-55-0, name is Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate, molecular formula is C6H12BF3KNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[01262] A mixture of 5- [2-chloro-5-(trifluoromethoxy)pyridin-4-yl] -2-(trifluoromethyl)pyrimidine (390 mg, 1.13 mmol, 1.00 equiv), potassium tert-butyl N-[(trifluoroboranuidyl)methyl]carbamate (350 mg, 1.47 mmol, 1.30 equiv), sodium carbonate (359 mg, 3.38 mmol, 2.98 equiv), and Pd(PPh3)2C12 (79 mg, 0.11 mmol, 0.09 equiv) in ethanol (5 mL)/water (0.5 mL) was stirred for 12 hours at 90C under nitrogen. The solid was filtered off. The filtrate was diluted with water, extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by a silica gel colunm eluting with ethyl acetate/petroleum ether (2/1) to afford the title compound (200mg, 40%) as a light yellow solid. LCMS [M+H] 439.
The synthetic route of 1314538-55-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
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