Application of 2895-21-8, A common heterocyclic compound, 2895-21-8, name is N-Isopropyl-2-chloroacetamide, molecular formula is C5H10ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 1d (18 mg, 0.08 mmol) was dissolved in 1.5 mL of DMF,Potassium carbonate (22.2 mg, 0.16 mmol) was added,80 reaction 30min,Compound 3a (13.1 mg, 0.10 mmol) was added,80 C overnight.After the reaction is over,Cool to room temperature.Add appropriate amount of water,Ethyl acetate was extracted three times,The organic phases were combined and washed with saturated brine,Dried over anhydrous magnesium sulfate,The crude product was distilled under reduced pressure.Separation and purification by column chromatography,25.0 mg of a white solid.Yield: 96.2%
The synthetic route of 2895-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Chen, Jianzhong; Xie, Xin; Qian, Haiyan; Chen, Lili; Wang, Zhilong; (42 pag.)CN106167497; (2016); A;,
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