Reference of 40724-47-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40724-47-8, name is 4-Bromomethylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.
[0330] Isopropyl 2-(4-bromo-3 -(3 -isopropoxyphenyl)- 1H-pyrazol- 1 -yl)thiazole-4- carboxylate (520 mg, 1.15 mmol) was dissolved in anhydrous THF ( 5 mL) and potassium acetate (340 mg, 3.46 mmol), PdC12(dppf) (0.9 mg, 0.0011 mmol) and bis(pinacolato)diborane (408 mg, 1.61 mmol) were added. The vial was purged with argon for 5 mm. The reaction was heated at 100 ¡ãC for 2h. The reaction mixture was diluted with ethyl acetate and filtered through a plug of celite. The solvent was removed by rotary evaporator and purified by flash chromatography (Combi-flash Rf, hexane/ethyl acetate, 0- 40percent gradient) to give a mixture of isopropyl 2-(3-(3-isopropoxyphenyl)-4-(4,4,5,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 1 H-pyrazol- 1 -yl)thiazole-4-carboxylate and isopropyl 2-(3 -(3 -isopropoxyphenyl)- 1 H-pyrazol- 1 -yl)thiazole-4-carboxylate.
The chemical industry reduces the impact on the environment during synthesis 4-Bromomethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; VANDERBILT UNIVERSITY; MALONEY, David J.; JADHAV, Ajit; BANTUKALLU, Ganesha Rai; BRIMACOMBE, Kyle Ryan; MOTT, Bryan T.; YANG, Shyh Ming; URBAN, Daniel Jason; HU, Xin; SIMEONOV, Anton; KOUZNETSOVA, Jennifer L.; WATERSON, Alex Gregory; SULIKOWSKI, Gary Allen; KIM, Kwangho; CHRISTOV, Plamen; JANA, Somnath; (387 pag.)WO2016/109559; (2016); A2;,
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