Adding a certain compound to certain chemical reactions, such as: 37045-73-1, name is 3-(Methylsulfonamido)aniline, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37045-73-1, Application In Synthesis of 3-(Methylsulfonamido)aniline
In a 1000 mL four-necked flask with mechanical stirring and a thermometer,Add 700g of water,Methanesulfonamidoaniline 149g(content 80%, 0.64 mol),Calcium carbonate 150g (1.50mol),Stir well and then as solution A,Transfered to the pipeline reactor by screw pump A,At the same time pumping liquid 1-chlorohexane 163g (1.35mol),Solution A and 1-chlorohexane are fed with screw pump A and screw pump B, respectively.The mass flow rate ratio of the control solution A to 1-chlorohexane was 6.1:1.0.The pipeline reactor has a pipeline reaction section providing a chemical reaction site, and the solution A and 1-chlorohexane are continuously reacted in the pipeline reaction section.Keep the temperature of the pipeline reaction section at 135 C,Control the residence time of the reaction solution to 10 min,Cooled, extracted with 800 mL of 2-methyltetrahydrofuran.The combined organic phases are concentrated under reduced pressure.Obtaining dialkylaminomethanesulfonanilide214.1g,97.6%,The yield was 94.5%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Methylsulfonamido)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JIANGSU DIAN CHEMICAL CO LTD; Jiangsu Di’an Chemical Co., Ltd.; ZHEJIANG SHANYU TECH CO LTD; Zhejiang Shanyu Technology Co., Ltd.; TAO ANNI; Tao Anni; GUO HAIBIN; Guo Haibin; WEI BIN; Wei Bin; LI JIAN; Li Jian; ZHENG TUCAI; Zheng Tucai; XU XUMING; Xu Xuming; HU XIAOKUI; Hu Xiaokui; (6 pag.)CN108299250; (2018); A;,
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