In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2832-19-1, name is 2-Chloro-N-(hydroxymethyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Chloro-N-(hydroxymethyl)acetamide
The starting material was prepared as follows: 2-Chloro-N-(hydroxymethyl)-acetamide (0.342 g; 2.7 mmol), triphenylphosphine (1.1 g; 4.19 mmol) and DEAD (0.6 ml; 4.19 mmol) were added to a solution of N-acetyl-colchicinol (0.3 g; 0.84 mmol) in dichloromethane (20 ml) under argon atmosphere. The mixture was stirred at ambient temperature for 2 hours, evaporated and purified by flash chromatography eluding with ethyl acetate/dichloromethane (50/50) and dichloromethane/methanol (98/2) to give (1). Yield: 76 % MS-ESI: 485.1 [MH]+
The synthetic route of 2832-19-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Angiogene Pharmaceuticals Ltd; EP1140745; (2003); B1;,
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