Electric Literature of 112101-81-2,Some common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2.6. Tamsulosin; I IV yield 50% 11 220 g (0.88 mol) of intermediate IV and 84 g (0.79 mol) of sodium carbonate and N, N- dimethylformamide (1500 ml) are added to 208 g (0.85 mol) of intermediate I. The reaction mixture is stirred at 70 C for 5 hours. Water is added to the reaction mixture and product II is extracted with ethylacetate. The evaporation residue is stirred in ethanol and after sucking off, the yield is 173.9 g (50 %) of crude base II. The method according to CZ 291802. The yield is, for comparison, also calculated on the crude base. The reaction takes place at 60 to 70 C for 5 hours and the product is not purified with the demanding column chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, its application will become more common.
Reference:
Patent; ZENTIVA, A.S.; WO2005/75415; (2005); A1;,
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