These common heterocyclic compound, 5466-88-6, name is 2H-1,4-Benzoxazin-3(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2H-1,4-Benzoxazin-3(4H)-one
To a stirred solution of 4H-Benzo[1 ,4]oxazin-3-one (2.5 g, 16.77 mmol) in DMF (10 mL) was added potassium tert-butoxide (2.81 g, 25.16 mmol) at 0 C. After stirring for 5 min, methyl iodide (3.54 g, 25.16 mmol) was added and the reaction mixture was stirred for another 3h. The reaction was quenched by addition of water and extracted with ethyl acetate (30 x 2 ml). The organic layer was washed with water (20 mL), and evaporated to get a crude product 2.2 g.
The synthetic route of 2H-1,4-Benzoxazin-3(4H)-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BEBERNITZ, Gregory Raymond; BOCK, Mark G.; BHUNIYA, Debnath; DATRANGE, Laxmikant; KURHADE, Suresh Eknath; PALLE, P. Venkata; REDDY, Dumbala Srinivas; WO2011/48148; (2011); A2;,
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