Related Products of 72179-84-1, These common heterocyclic compound, 72179-84-1, name is (Methylsulfamoyl)amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: N-Alkylsulfamide 7 (3.63mmol, 1equiv) was added to a stirred solution of arylaldehyde (4.00mmol, 1.1equiv) and Ti(OEt)4 (1.95g, 7.26mmol, 2equiv) in THF (10mL). The solution was stirred at reflux for 7h, allowed to cool and then poured into stirred brine (100mL), EtOAc (50mL) was added and the mixture was stirred vigorously. The mixture was then filtered through Celite and flushed with further EtOAc. The filtrate was separated and the aqueous layer was back extracted with EtOAc (50mL). The combined organic layers were washed with brine (50mL), dried (Na2SO4) and concentrated to a cream solid. Purification by column chromatography or trituration gave the products as colourless to cream solids (yellow for 9f).
Statistics shows that (Methylsulfamoyl)amine is playing an increasingly important role. we look forward to future research findings about 72179-84-1.
Reference:
Article; Crampton, Rosemary H.; Fox, Martin; Woodward, Simon; Tetrahedron Asymmetry; vol. 24; 9-10; (2013); p. 599 – 605;,
Amide – Wikipedia,
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