Adding a certain compound to certain chemical reactions, such as: 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75175-77-8, Recommanded Product: 75175-77-8
General procedure: Formamidine acetate (9.9 g, 0.096 mol) and sodium ethoxide(10.9 g, 0.16 mol) were dissolved in ethanol at 70 C for 1 h. Then2a-i was added in the reaction solution slowly, refluxed for15-20 h and monitored by TLC. The solution was concentratedin vacuum, the residue was resolved with dichloromethane(300 mL), washed with brine (60 mL), dried over anhydrousNa2SO4, and concentrated in vacuum to give the light yellowsolids 3a-i.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, and friends who are interested can also refer to it.
Reference:
Article; Zhu, Wufu; Wang, Wenhui; Xu, Shan; Wang, Jianqiang; Tang, Qidong; Wu, Chunjiang; Zhao, Yanfang; Zheng, Pengwu; Bioorganic and Medicinal Chemistry; vol. 24; 8; (2016); p. 1749 – 1756;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics