Some common heterocyclic compound, 389890-42-0, name is tert-Butyl (trans-3-hydroxycyclobutyl)carbamate, molecular formula is C9H17NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of tert-Butyl (trans-3-hydroxycyclobutyl)carbamate
triethyl amine (6.8 g, 67.29 mmol) was added to a suspension of trans -tert-butyl -3- hydroxy cyclobutyl carbamate (4.2 g, 22.43 mmol) in DCM (100 mL) followed by dropwise addition of methanesulfonyl chloride (3.08 g, 26.91 mmol) at -10 C and the reaction mixture was stirred at -10 C for 2h. The reaction mixture was diluted with DCM (100 mL) and washed with water (50 mL) followed by brine (30 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to obtain the crude product (3.4 g, crude) as a yellow solid which was used as such in next step without purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 389890-42-0, its application will become more common.
Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; BASTOS, Cecilia, M.; MUNOZ, Benito; TAIT, Bradley; (178 pag.)WO2016/115090; (2016); A1;,
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