Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 915087-25-1, name is 4-Amino-2-fluoro-N-methylbenzamide, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks
Example 3: Preparation of formula 4 TMSCN [74 g] was combined with N-methyl-2-fluro-4-aminobenzamide [formula 3, 50 g] in a clean and dried RBF. Acetic acid [250 ml] was slowly added dropwise to create frothing. Next, acetone [250 ml] was added and the reaction mass was heated to about 85 C. Heating continued until the reaction was complete. Next, the solvents were completely distilled off under vacuum (680 + 30 mm Hg). The resultant solid residue was cooled to room temperature, water [1000 ml] was added to the residue, and the reaction mass was stirred to get a free-flowing solid. The solid was filtered and washed with water to form a slurry. The slurry was then washed with tert-butyl methyl ether (TBME). The filtered cake was suck dried and the product dried under vacuum to result in formula 4.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MYLAN LABORATORIES LTD; WAGH, Ghanshyam; BODUPALLI, Murali; YEWALE, Sampat; DHANANJAY, Shinde; GADAKAR, Mahesh Kumar; GORE, Vinayak; DANDALA, Ramesh; (19 pag.)WO2016/38560; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics