Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 402-46-0, name is 4-Fluorobenzenesulfonamide, A new synthetic method of this compound is introduced below., COA of Formula: C6H6FNO2S
100 mg of 4-fluorobenzensulfonamide (0.71 mmol) dissolved with allylamine (434 muL, 5.71 mmol) in a sealed tube was heated at 110 C for 14 days. Then, the mixture was cooled to room temperature and was diluted with MeOH. The solvent was evaporated and the crude mixture was purified by combi-flash with the eluent petroleum ether/ethylacetate: 70/30, thereby obtaining compound 7 (62 mg, 51%) as an orange solid (mp: 74-76 C). 1H NMR (CD3COCD3, 400 MHz, ppm) d: 3.85 (td, CH2, J = 5.5 Hz, J = 1.7 Hz, H10), 5.12 (ddt, 1H, J = 10.3 Hz, J = 1.6 Hz, J = 1.6 Hz, H3′), 5.26 (ddt, 1H, J = 17.2 Hz, J = 1.8 Hz, J = 1.8 Hz, H3′), 5.89 (broad s, 1H, NH), 5.93 (m, CH, H2′), 6.16 (s, SO2NH2), 6.69 (d, 2CH, J = 8.9 Hz, H3 and H5), 7.60 (d, 2CH, J = 8.9 Hz, H2 and H6). 13C NMR (CD3COCD3, 100 MHz, ppm) d: 46.1 (CH2, C1′), 112.2 (2CH, C3 and C5), 116.1 (CH2, C30), 128.7 (2CH, C2 and C6), 131.7 (C1), 136.1 (CH, C2′), 152.5 (C4). MS (IES+, ACN): m/z 213 [M+H]+. HRMS (ESI, CH3OH): m/z 235.0518 (m/z theoretical: 235.05172) [M+Na]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Compain, Guillaume; Martin-Mingot, Agnes; Maresca, Alfonso; Thibaudeau, Sebastien; Supuran, Claudiu T.; Bioorganic and Medicinal Chemistry; vol. 21; 6; (2013); p. 1555 – 1563;,
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