Related Products of 13621-50-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13621-50-6, name is Ethyl 3-amino-3-thioxopropanoate, This compound has unique chemical properties. The synthetic route is as follows.
A solution of 4-chlorophenacyl bromide (0.79 g, 3.38 mmol) and ethyl-3- amino-3-thioxopropanoate (0.50 g, 3.38 mmol) in EtOH (10 mL) was heated to 75C for 2 h under an atmosphere of N2. At the completion of the reaction the EtOH was evaporated, water was added and the mixture was washed with EtOAc (3 x 50 mL). The combined organic phases were washed with water and brine, dried over a2S04, filtered and concentrated. The crude residue was purified by silica chromatography (5% EtOAc/hexane) to afford ethyl 2-(4-(4-chlorophenyl)thiazol-2-yl)acetate (0.67 g, 70%).
The chemical industry reduces the impact on the environment during synthesis Ethyl 3-amino-3-thioxopropanoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BIOTA SCIENTIFIC MANAGEMENT PTY LTD; HAYDON, David, John; CZAPLEWSKI, Lloyd, George; STOKES, Neil, Robert; DAVIES, David; COLLINS, Ian; PALMER, James, T; MITCHELL, Jeffrey, Peter; PITT, Gary Robert William; OFFERMANN, Daniel; WO2012/142671; (2012); A1;,
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