Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 337463-88-4, name is 6-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks
f) 6-Bromo-7-chloro-4H-pyrido[3,2-b][1,4]oxazin-3-one; 6-Bromo-4H-pyrido[3,2-b][1,4]oxazin-3-one (20g, 87.7 mmole) was dissolved inDMF (175 mL) and cooled in an ice bath. Chlorine gas was then slowly bubbled in for 45minutes, and then the saturated solution was stirred in the ice bath for 2 hours. Themixture was purged with nitrogen and slowly added with stirring to 1L of ice water whichcontained 10Og of Na2SO3, making sure to keep the temperature <15 C. After stirring 30minutes the product was filtered, washed thoroughly with water and dried to afford (22.5g,98%) of a white solid.1H NMR (400 MHz, DMSO-c/6): 4.76 (2H, s,), 7.78 (1H, s),11.71 (1H, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXO GROUP LIMITED; WO2006/14580; (2006); A1;,
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