337463-88-4, name is 6-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H5BrN2O2
To a stirred solution of lla (32 g, 0.139 mol) and 6-bromo-2H-pyrido[3,2-b][l,4]oxazin- 3(4H)-one (WO2017199265, 31.7 g, 0.139 mol) in dry l,4-dioxane (50 mL), were added t-butyl-X-Phos mesyl chloride complex( 5.5 g, 0.0069 mol) and sodium tert-butoxide (19.94 g, 0.207 mol) and was degassed for 20 mins. Then, it was heated in sealed tube at 100 C for 16 h. After completion of the reaction, reaction mixture was concentrated under reduced pressure. It was purified by column chromatography on silica gel (230-400 mesh, 25-30% ethyl acetate in pet ether) to afford lib (45.6 g, 86%). LC_MS Calculated for C17H25N3O5S1, 379.49, Observed 380.0. lH NMR (400 MHz, DMSO-d6). d 7.60 (d, J = 8.68 Hz, 1H), 7.43 (d, J = 8.68 Hz, 1H), 4.77-4.73 (m, 1H), 4.67 (s, 2H), 4.15-4.10 (m, 1H), 3.93-3.89 (m, 3H), 0.79 (s, 9H), 0.04 (s, 6H).
The synthetic route of 337463-88-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BUGWORKS RESEARCH INDIA PVT LTD; PEER MOHAMED, Shahul Hameed; BHARATHAM, Nagakumar; KATAGIHALLIMATH, Nainesh; SHARMA, Sreevalli; NANDISHAIAH, Radha; RAMACHANDRAN, Vasanthi; (116 pag.)WO2019/186590; (2019); A1;,
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