In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 42137-88-2 as follows. category: amides-buliding-blocks
N,N-Bis(2-chloroethyl)-p-toluenesulfonamide (171 mg, 0.576 mmol), potassium iodide (191 mg, 1.15 mmol) and K2C03 (159 mg, 1.15 mmol) were added to a stirring solution of N1- (5-chloro-4-(lH-indol-3-yl)pyrimidin-2-yl)bicyclo[3.2.1]octane-l,5-diamine_(195 mg, 0.384 mmol). The resulting mixture was then heated at 130 C for 16h. The solution was cooled to room temperature, diluted with EtOAc (100 mL) and washed with H20 three times (50 mL). The organics were combined, dried over Na2S04, filtered and evaporated to dryness. The mixture was purified by Si02 column (DCM/EtOAc 0 to 60% gradient) and afforded the title compound (133 mg, 0.182 mmol, 47%) as an off white solid.
According to the analysis of related databases, 42137-88-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYROS PHARMACEUTICALS, INC.; SPROTT, Kevin; MARINEAU, Jason, J.; SCHMIDT, Darby; BRADLEY, Michael; CIBLAT, Stephane; SIDDIQUI, M., Arshad; KABRO, Anzhelika; LEBLANC, Melissa; LEGER, Serge; ROY, Stephanie; WINTER, Dana, K.; MILLER, Tom; RIPKA, Amy; LI, Dansu; WO2015/154039; (2015); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics