Related Products of 61903-11-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61903-11-5, name is 1-(1,4-Diazepan-1-yl)ethanone belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of the product of example Ii (160 mg), JV-acetylhomopiperazine (89 mg), DIPEA (370 muL) and HATU (192 mg) in dichloromethane (5 ml) was stirred at 400C for 1 h. The reaction mixture was diluted with ethyl acetate and washed with an aqueous HCl solution (0.2 M), water and brine. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel in heptane/ethyl acetate [10/0 ? 8/2 (v/v)] as eluent.Yield: 230 mg; hFSHRago (CHO luc) EC50 = 5.2 nM
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1,4-Diazepan-1-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; N.V. ORGANON; WO2009/98283; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics