Electric Literature of 14719-21-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
step 1: A single jar was charged with compound dG-I (0.25 g, 0.4 mmol) Lmmo 1) and Pd (PPh3) 4 (48 mg; 0.04 mmol) were weighed into a reaction vial, Vacuum, nitrogen protection, wrapped in aluminum, add 10ml DMF, Stirring dissolved, TEA (0. 088 g; 0.8 mmol) and trifluoroacetylpropargylamine (0.2 g; 1.2 mmol) were injected, 50 C stirring 13 hours after the end of the reaction, The residue was dissolved in of ethyl acetate, Washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution, Dried over anhydrous sodium sulfate, concentrated and purified by column chromatography [V (ethyl acetate): V (n-hexane) = 1: 3] To obtain 0.1 g of a white solid, dG (AP3), in a yield of 39%
The synthetic route of 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Jiao Tong University; SHEN, YUMEI; SHAO, ZHIFENG; GONG, BING; LIU, YAZHI; ZHAO, XIAODONG; JIANG, MIN; LI, XIAOWEI; TANG, DAONIAN; WU, XINYAN; (19 pag.)CN103601779; (2016); B;,
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