Reference of 72505-21-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72505-21-6, name is 4-(Trifluoromethyl)thiobenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Appropriate thiobenzamides or thioacetamides (1 mmol) and alpha-chloroacetoacetate 3 (150 mg, 1.2 mmol) were added to absolute ethanol (15 mL). The reaction mixture was heated at reflux for 24 h. After removal of solvent under reduced pressure, the residue was purified by silica gel chromatography using hexanes-ethyl acetate (7:3) to provide the desired compounds.
The synthetic route of 4-(Trifluoromethyl)thiobenzamide has been constantly updated, and we look forward to future research findings.
Reference:
Article; Mayhoub, Abdelrahman S.; Khaliq, Mansoora; Botting, Carolyn; Li, Ze; Kuhn, Richard J.; Cushman, Mark; Bioorganic and Medicinal Chemistry; vol. 19; 12; (2011); p. 3845 – 3854;,
Amide – Wikipedia,
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